CompletedPhase 4

To Compare the Efficacy of Drugs in Combination for Treating Irritable Bowel Syndrome Associated With Diarrhea

Pakistan162 participantsStarted 2023-01-03

Plain-language summary

The goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (IBS)-associated diarrhea. The main question to answer is: * Is there a significant difference in effect of different drug combinations in management of irritable bowel syndrome with diarrhea? Participants will be divided into 3 treatment groups. * Each group will be given a combination of drugs for 2 weeks * At the end of study, efficacy of different drug combinations and their potential side effects will be compared between the treatment groups

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Individual of both gender between the age of 18-50 years Diagnosed case of Irritable Bowel Syndrome associated with Diarrhea Exclusion Criteria: * Presence of co morbid diseases * Coronary Artery Disease (CAD) * Chronic Obstructive Pulmonary Disease (COPD) * Congestive Heart Failure (CHF) * Patients taking drugs which modify or aggravate symptoms of IBS (antidepressants, calcium channel blockers etc.) * Patients having hyperthyroidism \& gluten hypersensitivity * Patients with alarming symptoms, viz. history of fever, passage of blood in stool, loss of weight, any organic gastrointestinal disease in the recent past * Patients with recent change in bowel habits, patients on any other concomitant medication for abdominal pain, bowel disturbance or altering gastrointestinal motility and malignancy of any other organ * Patients with Irritable Bowel Disease and Celiac disease

What they're measuring

Overall Improvement in Frequency of Diarrhea

Timeframe: 2 Weeks

Overall Improvement in Characteristic of Diarrhea

Timeframe: 2 Weeks

Overall Improvement in Abdominal Pain

Timeframe: 2 Weeks

Compare Efficacy of Treatment Regimes in Treatment Groups

Timeframe: 4 Weeks

Trial details

NCT IDNCT05867550

SponsorBahria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03-27

View on ClinicalTrials.gov More Irritable Bowel Syndrome With Diarrhea trials

Plain-language summary

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.