RecruitingNot Applicable

Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

United States112 participantsStarted 2023-07-11

Plain-language summary

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

Who can participate

Age range

65 Years – 84 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 65 and 84 years old; * Weight ≥ 110 pounds; * Nonsmokers for at least 1 year; * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records; * Both English and Spanish speaking participants will be included in the recruitment; * Live in the Los Angeles County. Exclusion Criteria: * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's; * Currently have active cancer treatments; * The residential house has already had HEPA filters; * Participants will move out from the current residential address in the next 2 years; * Participants will spend more than 1 month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimens; * Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in blood pressure

Timeframe: Blood pressure will be monitored daily during each of the 9-month intervention

Change in carotid-femoral pulse wave velocity

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in augmentation index

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in von Willebrand factor

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in P-selectin

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Trial details

NCT IDNCT05867381

SponsorUniversity of Southern California

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06-30

Contact for this trial

Zhanghua Chen, PhD

323-442-2109 zhanghuc@usc.edu

View on ClinicalTrials.gov More Air Pollution trials

Who can participate

Age range

65 Years – 84 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in blood pressure

Timeframe: Blood pressure will be monitored daily during each of the 9-month intervention

Change in carotid-femoral pulse wave velocity

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in augmentation index

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in von Willebrand factor

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions

Change in P-selectin

Timeframe: At the baseline, in the middle (4.5 month after intervention) and immediately after each of the 9-month interventions