CompletedNot Applicable

Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)

United Kingdom177 participantsStarted 2023-07-03

Plain-language summary

The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1). The main questions it aims to answer are: * whether the size and structure of the muscles involved in swallowing differ to those without the disease * how the size and structure of muscles may associate with swallowing function and swallowing symptoms in this group. Participants will undergo a range of tests including: * Ultrasound (US) assessment of the muscles involved in swallowing * An x-ray swallowing study (known as videofluoroscopy) * Assessment of swallowing symptoms, including questionnaires * Assessments of mobility, activity and breathing * Assessments of quality of life and wellbeing

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Participants with DM1 Inclusion: * ≥18 years of age * genetically confirmed of DM1 * able to eat \& drink at least five sips of liquid by mouth at one time. Exclusion: * any condition or treatment other than DM1 that potentially influences swallowing muscle composition or function (e.g., a history of stroke or throat cancer). * any patients who are pregnant * patients with congenital or childhood DM1 * patients who are not able to eat or drink anything by mouth.

What they're measuring

Swallowing muscle (geniohyoid) size

Timeframe: 16 months

Swallowing muscle (geniohyoid) structure

Timeframe: 16 months

Trial details

NCT IDNCT05865483

SponsorUniversity College, London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-23

View on ClinicalTrials.gov More Myotonic Dystrophy 1 trials