Evaluation of Correlation Between Oculometric Measures and Clinical Assessment in Parkinson's Dis… (NCT05862649) | Clinical Trial Compass
CompletedNot Applicable
Evaluation of Correlation Between Oculometric Measures and Clinical Assessment in Parkinson's Disease
United States, Portugal, Spain300 participantsStarted 2023-08-21
Plain-language summary
This is a multicenter longitudinal study in about 300 patients with Idiopathic Parkinson's disease, who will be evaluated in several clinical centers with a clinical assessment and an oculometric examination during a time period with specific intervals. This study aims to evaluate the correlation between oculometric measures and clinical assessment over time, as well as the potential to detect early change in clinical status using an oculometric assessment.
Who can participate
Age range
40 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and women with idiopathic PD (Hoehn \& Yahr scale 1-2)
* Age between 40 and 85 years old
* 0 to 5 years' time since diagnosis
* Normal or corrected vision
* Ability to follow instructions
* Willing and able to sign an informed consent form
* No anticipated changes in PD medications from baseline throughout the study duration based on clinical status during screening
* If treated, stable on treatment for at least 3 months
Exclusion Criteria:
* Inability to sit for 40 minutes on a chair in a calm manner
* Personal or 1st degree relative history of epilepsy
* Additional neurological diseases
* Drug or alcohol abuse (except for using medical cannabis during 24 hours prior NL examination date)
* Pregnancy or a potential pregnancy (self-declaration)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change of saccadic latency over time as evaluated during visits
Timeframe: 12 months
2
Change of anti-saccadic error rates over time as evaluated during visits
Timeframe: 12 months
3
Change of smooth pursuit speed over time as evaluated during visits
Timeframe: 12 months
4
Correlation between MDS-UPDRS score and its parts with saccadic latency
Timeframe: 12 months
5
Correlation between MDS-UPDRS score and its parts with anti-saccadic error rates
Timeframe: 12 months
6
Correlation between MDS-UPDRS score and its parts with smooth pursuit