UnknownPhase 2

The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography

China240 participantsStarted 2023-05-24

Plain-language summary

Rationale:Papaverine is effective on radial artery spasm during transradial cerebral angiography. Purpose: This multicenter, randomized, placebo-controlled, double blind, phase 2b trial aims to investigate the effect and safety of papaverine in treating radial artery spasm during transradial cerebral angiography.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. All patients scheduled for cerebral angiography will be eligible for screening.
✓. Participant is willing and is able to give informed consent for participating in the trial.
✓. Male or Female, aged 18 years or above.

Exclusion criteria

✕. Any patient with negative modified Allen test
✕. Altered liver function
✕. atrioventricular heart block III degree
✕. Suspected or confirmed cerebral hemorrhage patients
✕. Hemodynamic Instability : systolic pressure \< 100 mmHg, heart rate \> 100 bpm, tachycardia uncontrollable.
✕. Patients with cerebral edema and increased intracranial pressure within 24 hours to 2 weeks after stroke
✕. Coronary artery bypass grafting(CABG) operation history and whose right radial artery is missing as a "bridge vessel"
✕. Severe skin musculoskeletal malformation of forearm or failure to complete radial artery puncture and sheath placement for other reasons

What they're measuring

The incidence of RAS

Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.

Trial details

NCT IDNCT05861765

SponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-30

Contact for this trial

Yamei Tang, PhD

+86-020-34070569 tangym@mail.sysu.edu.cn

View on ClinicalTrials.gov More Radial Artery Spasm trials