Background and objective: Tea is the second most consumed drink in the world after water. Gingivitis is among the most common infectious diseases. In this clinical study, Chlorhexidine Gluconate (CHX) was chosen as the positive control group and the clinical and biochemical efficacy of mouthwashes with green tea, white tea and essential oil (EO) as the active ingredients were aimed to be examined comprehensively. Methods: 112 participants with gingivitis were randomly assigned to 4 different groups that different mouthwashes were used for 4 weeks. CHX-MW group (0.12% CHX, as a positive control group), EO-MW group (Listerine), GT-MW group (5% Green tea), and WT-MW group (5% White tea). The effects of the mouthwashes on plaque, inflammation, and dental staining were evaluated by indexed scores at the beginning and the end of the 4th week. In addition, markers related to gingival inflammation (IL-1beta, MMP-8) and oxidative stress (TOS, TAS, OSI (TOS/TAS)) were evaluated on samples from the gingival crevicular fluid.
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Papillary bleeding index
Timeframe: changes of clinical findings from the beginning to 4th week
Plaque index
Timeframe: changes of clinical findings from the beginning to 4th week
Probing pocket depth
Timeframe: changes of clinical findings from the beginning to 4th week
Tooth staining index
Timeframe: changes of clinical findings from the beginning to 4th week
The staining index of the tongue
Timeframe: changes of clinical findings from the beginning to 4th week
Biochemical results:IL-1beta(ng/mL)
Timeframe: changes of biochemical findings from the beginning to 4th week
Biochemical results:MMP-8(ng/mL)
Timeframe: changes of biochemical findings from the beginning to 4th week
Biochemical results:Total Oxidatif Status(μmol H2O2 Equiv./L)
Timeframe: changes of biochemical findings from the beginning to 4th week
Biochemical results:Total Antioxidative Status(μmol Trolox. Equiv./L)
Timeframe: changes of biochemical findings from the beginning to 4th week
Biochemical results:Oxidative Stress Index[(μmol H2O2 Equiv./L)/(μmol Trolox. Equiv./L)]
Timeframe: changes of biochemical findings from the beginning to 4th week