Active — Not RecruitingNot Applicable

Psychosis TMS Study

United States20 participantsStarted 2023-04-04

Plain-language summary

The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.

Who can participate

Age range18 Years – 35 Years

SexALL

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Inclusion Criteria: * Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, and schizophreniform disorder within first ten years of onset of psychotic symptoms. * Ability to provide informed consent Exclusion Criteria: * TMS incompatibility including metallic implants in head and neck, cardiac pacemakers, history of seizures, pregnancy. * MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metal implants, intrauterine devices, tattoos containing metal ink, pregnancy, and claustrophobia * Severe substance abuse within 3 months (nicotine allowed) * Unstable medical or neurologic illness that would preclude participation in study procedures

What they're measuring

Working memory accuracy

Timeframe: 2 hours

Reaction time during working memory

Timeframe: 2 hours

Resting state functional connectivity between the left inferior parietal lobule and the regions of the frontoparietal control network

Timeframe: 2 hours

Resting state functional connectivity within the default mode network

Timeframe: 2 hours

Trial details

NCT IDNCT05857137

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-15

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