Creatine Supplementation for Improved Voice Performance in the Elderly (NCT05856916) | Clinical Trial Compass
SuspendedNot Applicable
Creatine Supplementation for Improved Voice Performance in the Elderly
Stopped: Project is on indefinite hold due to a lack of funding
United States20 participantsStarted 2026-05-01
Plain-language summary
The primary objective of this study is to determine if creatine supplementation improves acoustic, auditory perceptual, physiologic, and patient-reported outcome measures in patients over 65 years of age. In the study, 20 participants will be enrolled and randomly assigned to receive either creatine or placebo.
Who can participate
Age range
65 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age 65 years or older
. Desiring to participate in voice therapy
Exclusion criteria
. Lesions or abnormalities of the larynx not attributable to normal aging
. Pre-existing renal disease
. Pre-existing liver disease
. Congestive heart failure
. Blood urea nitrogen (BUN), creatine, alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) over reference range in the last 6 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in Voice Handicap Index (VHI)-10 Scores
Timeframe: Baseline, Week 10
2
Average Expert Rating of Change in Mucosal Wave
Timeframe: Week 10
3
Average Expert Rating of Change in Vocal Fold Atrophy
Timeframe: Week 10
4
Average Expert Rating of Change in Glottal Closure
Timeframe: Week 10
5
Average Phonatory Pressure during Aerodynamic Analysis of Voice
Timeframe: Up to Week 10
6
Average Decibel (dB) Output during Aerodynamic Analysis of Voice