RecruitingPhase 4

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

United States69 participantsStarted 2023-06-19

Plain-language summary

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system). Exclusion Criteria: * Patients who refuse research participation. * Patients who are pregnant. * Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

What they're measuring

Change in Young's modulus (derived from shear wave speed)

Timeframe: Baseline, 10 min post-opioid

Trial details

NCT IDNCT05856136

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-08

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