UnknownNot Applicable

HVNI for Successful Weaning in Respiratory Failure

Egypt40 participantsStarted 2023-04-01

Plain-language summary

The goal of this randomized active-controlled study is to investigate the role of high velocity nasal insufflation (HVNI) in the immediate post-extubation period and compare it with non-invasive positive pressure ventilation (NIPPV) as regards to weaning success rate. The study will recruit those who have been on invasive mechanical ventilation for at least 3 days and with a high risk of weaning failure.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \>65 years old
✓. BMI \>30
✓. APACHE II score at extubation \>12
✓. ≥2 comorbidities
✓. Endotracheal intubation \> 7 days
✓. ≥1 failed attempts at disconnection from mechanical ventilation
✓. Chronic lung disease e.g., COPD, OHS, etc.
✓. Underlying left ventricular dysfunction

Exclusion criteria

✕. Non-respiratory failure patients
✕. Patients judged to need a tracheostomy (poor airway reflexes or copious secretions)
✕. Patients who cannot tolerate an oral or nasal interface (facial trauma or perforated nasal septum)
✕. Patients with increased risk of aspiration, agitation, or uncooperativeness
✕. End stage disease with life expectancy less than 6 months

What they're measuring

Failure of HVNI / NIPPV within 72 hours of initiation

Timeframe: within 72 hours from start of either allocated modality

Trial details

NCT IDNCT05855213

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03

View on ClinicalTrials.gov More Respiratory Failure trials