Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2

DM 2 Inclusion Criteria: * Age 30-65 years old * Diagnosis of DM1 or DM2 is based on genetic testing and/or clinical criteria. If the diagnosis is based on clinical criteria, positive DM2 genetic testing is required in first-degree relatives * Symptoms or clinical findings of proximal muscle weakness * Ambulate independently (a cane or walking stick is permitted) * Able to provide informed consent for participation in the study DM1 Inclusion Criteria: * Only individuals who are 30-65 years old will be eligible to participate for the full study protocol * Diagnosis of adult-onset DM1 is based on genetic testing or clinical criteria. If the diagnosis is based on clinical criteria, positive DM1 genetic testing is required in first-degree relatives * The onset of first symptoms must be between the 2nd and 4th decades of life * Symptoms or clinical findings of distal muscle weakness and myotonia * Ambulate independently (a cane or walking stick is permitted) * Able to provide informed consent for participation in the study DM 1 Exclusion Criteria: * Congenital or juvenile-onset DM1 (onset of first symptom \< 20-year-old) * Individuals with a prior diagnosis of dementia, seizure, stroke, multiple sclerosis, Parkinson's Disease, or other neurodegenerative diseases * Individuals with active psychiatric illness or alcohol/substance abuse. * On medications with substantial sedative or cognitive side effects unless the doses have been stable for at least 3 months before the study v…