CompletedNot Applicable

Comparison of Three Methods of PEEP Titration During One Lung Ventilation in Prone Position

Egypt42 participantsStarted 2023-06-05

Plain-language summary

One-lung ventilation and prone positioning during thoracoscopic esophagectomy is associated with pulmonary complications so lung protection is strongly recommended. Individualization the optimal PEEP level according to the respira¬tory condition of patients has gradually attracted the attention of clinicians. The aim of this study is to compare and evaluate the differences between three different PEEP values in patients who will undergo thoracoscopic esophagectomy receiving either constant PEEP or driving pressure guided individualized PEEP or oxygenation guided individualized PEEP.

Who can participate

Age range40 Years – 65 Years

SexALL

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Inclusion Criteria: * American Society of Anesthesiology (ASA) (grade 1or 2) patients. * Scheduled for elective thoracoscopic esophagectomy treated with one lung ventilation in prone position and surgery of expected duration greater than 1 h. * Body mass index (BMI) less than 30 kg/m2. Exclusion Criteria: * Patient's refusal. * Altered mental status or un-cooperative patients. * History of known sensitivity to the used anesthetics. * Significant cardiac dysfunction, hepatic, or renal impairment. * History of severe chronic obstructive pulmonary disease. * History of severe or uncontrolled bronchial asthma. * History of severe restrictive lung disease. * History of pulmonary metastases. * History of any thoracic surgery. * Need for chest drainage prior to surgery.

What they're measuring

lung ultrasound score

Timeframe: Up to 5 min before leaving the post anesthesia care unit (PACU)

Trial details

NCT IDNCT05851612

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-10