CompletedNot Applicable

The Effect of Sleep Deprivation on Passive and Active Functions and Distance Modulation of the Vestibulo-Ocular Reflex

Israel17 participantsStarted 2022-05-19

Plain-language summary

The goal of this cross-over clinical trial is to evaluate the effect of 24 hours sleep deprivation on the Vestibulo-Ocular Reflex (VOR) in healthy participants. The main questions it aims to answer are: 1. The effect of sleep deprivation on vestibular function. 2. The difference between passive and active VOR function following sleep deprivation. 3. The vergence mediated modulation ability of the VOR following sleep deprivation. 4. The effect of sleep deprivation on behavioral VOR function. Participants will be tested before and after a normal night sleep and during 24 hours of sleep deprivation.

Who can participate

Age range

30 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 30-60 years old * Healthy * Persons who are not night shift workers * Persons who are not used to but can keep awake for 24 hours Exclusion Criteria: * Night shift workers * Vestibular system deficiency in vHIT test * Active neurological disease * Any orthopedic deficit in the cervical area preventing a proper vHIT examination * A diagnosed sleep disorder or \>5 score in the Pittsburgh sleep quality questionnaire Hebrew version (PSQI)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

VOR gain

Timeframe: 9pm before and 6am after normal sleep. 9pm, 2am and 6am during sleep deprivation.

Trial details

NCT IDNCT05850767

SponsorYoav Gimon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-06

View on ClinicalTrials.gov More Healthy trials