The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer

Inclusion Criteria: * Having a Diabetic ulcer grade II and IV based on Wagner's classification on the sole, medial, or lateral part of the foot (including all surfaces of the toes) * Having a single ulcer on the feet and extremities (toes, soles, heels) with no significant reduction in ulcer size (\<20%) despite the use of best treatment methods for at least four weeks * If there is more than one non-healing wound, choose the largest wound * The size of the wound surface (length × width) between 2 cm2 and 20 cm2 * No smoking, alcohol, and drug addiction based on the patient's self-report * Not taking drugs that may interfere with wound healing, such as Corticosteroids, immunosuppressants, and cytotoxic agents * Not having a concurrent chronic disease that may cause problems in wound healing, such as cancers, vasculitis, no history of known severe kidney, liver, and heart disease, such as liver cirrhosis, active hepatitis, dialysis, etc. * Not taking antidepressants * Insensitivity to milk lactose * Not having Glucose 6-phosphate dehydrogenase (G6PD) deficiency * Confirmed, informed, signed consent form * Ankle Brachial Index (ABI) higher than or equal to 0.7 Exclusion Criteria: * Do not be treated with methylene blue * The confirmed presence of osteomyelitis, or if there is suspicion of osteomyelitis * The subject is pregnant or intends to become pregnant during the test period * The patient is known to have mental, developmental, physical, and emotional disorders * The oc…