CompletedNot Applicable

Optic Nerve Sheath Diameter for Prediction of Sepsis Associated Encephalopathy

Egypt89 participantsStarted 2023-05-03

Plain-language summary

Sepsis-associated brain dysfunction (SABD)with increased intracranial pressure is a complex pathology that can lead to unfavourable outcome. Although direct measurement of intracranial pressure using an intra-ventricular catheter remains the gold standard, it is burdened with potential serious complications due to its invasiveness. Ultrasonic measurement of optic nerve sheath diameter (ONSD) is a non-invasive method for ICP monitoring. Screening for SABD is crucial for early diagnosis and management, measurement of ONSD can detect elevated intracranial pressure in septic patients. Intracranial hypertension in septic patients might be a sign of SABD. Using ONSD for SABD screening requires further research. So, we hypothesized that ONSD could be used as an objective screening tool to predict and early diagnose SABD in adult septic patients.

Who can participate

Age range21 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient acceptance. * Age 21- 70 years old. * Patients diagnosed with sepsis For diagnosis of sepsis and septic shock, the third international definition and appropriate diagnostic criteria was used. Sepsis was defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection, and it is suspected in an acutely deteriorating patient in whom there is clinical evidence or strong suspicion of infection. Septic shock was defined as the need for vasopressors or vasoactive medication to maintain a mean arterial blood pressure of 65 mmHg or higher after adequate fluid resuscitation, with the presence of a high lactate (\>2 mmol/l). Exclusion Criteria: * Patient refusal. * Ocular wound * History of prior ocular trauma or surgery * Conjunctival edema or orbital edema * Vitreous hemorrhage * Central nervous system (CNS) infection * Cerebrovascular accident * Brain trauma * Any previous neurosurgical procedure

What they're measuring

correlation between ONSD measurements and the occurrence of SAE

Timeframe: 10 days

Trial details

NCT IDNCT05849831

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2024-05-30