Although most infected people survive the infection, many have persistent sequelae or symptoms, which cause disability or decreased quality of life. The World Health Organization has called on countries to prioritize the rehabilitation of the consequences of COVID-19 in both the medium and long term, as this chronicity is expected to impact the health public and the economy in the coming years. RehabCOVID (also referred to as RehabNautilus) is born from the need to provide solutions to persistent cognitive impairment symptoms of people who have suffered from COVID-19. Thus, we will offer people with long COVID that accomplish inclusion/exclusion criteria to participate in a randomized clinical trial to evaluate the effectiveness of cognitive stimulation therapy combined with physical exercise and mindfulness. The current project is a single-blind randomized control study, where we will compare two combined interventions with a control group that will encompass different functional, structural, and biochemical changes and interactions in the brain. We will study the effects that this combined intervention produces in the brain. We expect to gain more insight into the specific neuroplasticity mechanisms of cognitive persistent COVID symptoms.
Age range
18 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Differences between groups in scores of global cognition
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of selective attention, inhibition, and processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Visual scanning and processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Executive functioning and cognitive flexibility
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of auditory attention
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of working memory_DSB
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Perceptual Reasoning
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of sustained attention and impulsivity
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of verbal memory and learning
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of phonetic fluency
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of semantic verbal fluency
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of memory and everyday forgetfulness
Timeframe: Before the intervention and 12 weeks later