Although most infected people survive the infection, many have persistent sequelae or symptoms, which cause disability or decreased quality of life. The World Health Organization has called on countries to prioritize the rehabilitation of the consequences of COVID-19 in both the medium and long term, as this chronicity is expected to impact the health public and the economy in the coming years. RehabCOVID (also referred to as RehabNautilus) is born from the need to provide solutions to persistent cognitive impairment symptoms of people who have suffered from COVID-19. Thus, we will offer people with long COVID that accomplish inclusion/exclusion criteria to participate in a randomized clinical trial to evaluate the effectiveness of cognitive stimulation therapy combined with physical exercise and mindfulness. The current project is a single-blind randomized control study, where we will compare two combined interventions with a control group that will encompass different functional, structural, and biochemical changes and interactions in the brain. We will study the effects that this combined intervention produces in the brain. We expect to gain more insight into the specific neuroplasticity mechanisms of cognitive persistent COVID symptoms.
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Differences between groups in scores of global cognition
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of selective attention, inhibition, and processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Visual scanning and processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Executive functioning and cognitive flexibility
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of auditory attention
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of working memory_DSB
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of Perceptual Reasoning
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of sustained attention and impulsivity
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of processing speed
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of verbal memory and learning
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of phonetic fluency
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of semantic verbal fluency
Timeframe: Before the intervention and 12 weeks later
Differences between groups in scores of memory and everyday forgetfulness
Timeframe: Before the intervention and 12 weeks later