Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance use disorders lead to impairments in these same cognitive processes. Recent large-scale research initiatives in forensic settings have begun to identify substance abuse and psychopathy-related disruption in the neural mechanisms involved in moral decision-making processes, and associations between these neural networks and future relapse and antisocial behavior. Here the investigators extend prior work (with incarcerated men) to examine these issues among incarcerated women in order to better understand sex differences. This project addresses the overall lack of neurocognitive research in criminal offenders with substance use disorders, thereby focusing on a major public health issue in an underserved and understudied population.
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Gray matter volume during MRI scan & stimulant use
Timeframe: During MRI procedure
White matter integrity during MRI scan & stimulant use
Timeframe: During MRI procedure
Functional brain response during MRI scan & stimulant use during simple linguistic decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & stimulant use during simple picture decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & stimulant use during moral linguistic decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & stimulant use during moral picture decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & stimulant use during simple linguistic decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & stimulant use during simple picture decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & stimulant use during moral linguistic decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & stimulant use during moral picture decision task
Timeframe: During MRI procedure
Gray matter volume during MRI scan & psychopathic traits
Timeframe: During MRI procedure
White matter integrity during MRI scan & psychopathic traits
Timeframe: During MRI procedure
Functional brain response during MRI scan & psychopathic traits during simple linguistic decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & psychopathic traits during simple picture decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & psychopathic traits during moral linguistic decision task
Timeframe: During MRI procedure
Functional brain response during MRI scan & psychopathic traits during moral picture decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & psychopathic traits during simple linguistic decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & psychopathic traits during simple picture decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & psychopathic traits during moral linguistic decision task
Timeframe: During MRI procedure
Functional connectivity during MRI scan & psychopathic traits during moral picture decision task
Timeframe: During MRI procedure
Relapse to/change in stimulant use post-release
Timeframe: Every 3 months post release for duration of grant (5 years)
Return to/change in antisocial behavior post-release
Timeframe: Every 3 months post release for duration of grant (5 years)