CompletedNot Applicable

MMP-9, TIMP-9 in Lung Imaging and Functional of COVID-19

Indonesia78 participantsStarted 2021-03-15

Plain-language summary

This study aims to determine the role of the extracellular matrix in lung abnormalities in COVID-19 patients. Anatomical abnormalities of the lungs can be observed by the presence of abnormalities on a chest x-ray that is scored using the Brixia index. The presence of COVID-19 pneumonia can impact oxygenation disorders. It is hoped that knowing the relationship between biomarkers that affect the extracellular matrix and anatomical and functional abnormalities can open up new insights into new therapeutic opportunities. The balance of MMP-9 and TIMP-1 has been studied in relation to several lung diseases other than COVID-19.

Who can participate

Age range

21 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The patient is infected with COVID-19 with positive RT-PCR Swab results * Age 21-70 years * Men or Women * Various degrees of severity (mild, moderate, severe, critical) and comorbidities * the Chest X-ray was done * Willing to participate in research (signing informed consent) Exclusion Criteria: * The patient is TB active or has been treated for pulmonary TB * Patients with a history of ILD clinically * Patients with a history of asthma or COPD * Pregnant women * HIV/AIDS patients

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Anatomical abnormalities of the lungs.

Timeframe: Chest X-Ray checked 2-4 hours during admission in emergency room.

Functional abnormalities of the lungs.

Timeframe: Oxygen use and blood gas analysis checked 1-2 hours during admission in emergency room.

Trial details

NCT IDNCT05844215

SponsorUniversitas Airlangga

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-24

View on ClinicalTrials.gov More Pulmonary Infection trials