CompletedNot Applicable

Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study

Germany120 participantsStarted 2023-03-07

Plain-language summary

In this clinical proof-of-concept study, the aim is to investigate the efficacy of a hypotension avoidance strategy to prevent post-induction hypotension. Specifically, it will be investigate how much postinduction hypotension occurs when using a hypotension avoidance strategy - combining continuous intraarterial blood pressure monitoring, careful administration of anesthetic drugs, and continuous administration of norepinephrine to treat hypotension - in high-risk patients having elective non-cardiac surgery.

Who can participate

Age range45 Years – 130 Years

SexALL

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Inclusion Criteria: * American Society of Anesthesiologists physical status classification III or higher, and in whom intraarterial blood pressure monitoring is planned for clinical indication Exclusion Criteria: * Emergency surgery * Transplant surgery * History of organ transplant * Sepsis * Pregnancy * Contraindications for the use of propofol * Rapid sequence induction

What they're measuring

Area under a MAP of 65 mmHg

Timeframe: First 15 minutes of induction of general anesthesia

Trial details

NCT IDNCT05842759

SponsorUniversitätsklinikum Hamburg-Eppendorf

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-07

View on ClinicalTrials.gov More Hypotension trials