RecruitingNot Applicable

Coronary Flow During Rapid Heart Rates

United Kingdom70 participantsStarted 2023-08-01

Plain-language summary

The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Able to give valid consent * Referred for coronary angiography or coronary angioplasty * Suitable for percutaneous physiological interrogation and PCI when clinically indicated Exclusion Criteria: * Unable to give valid consent * Pregnant or breastfeeding women * Unstable coronary artery disease (acute coronary syndrome) * Severe multivessel coronary artery disease suitable for coronary artery bypass grafting * Severe heart valve disease * Severe (NYHA IV) heart failure

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in coronary flow in participants with different levels of coronary microvascular function.

Timeframe: At baseline and during simulated VT

Change in coronary flow in participants immediately before and after PCI

Timeframe: At baseline and during simulated VT, immediately before PCI and after PCI

Change in blood pressure in participants with different levels of coronary microvascular function.

Timeframe: At baseline and during simulated VT

Change in blood pressure in participants before and after PCI

Timeframe: At baseline and during simulated VT, immediately before PCI and after PCI

Trial details

NCT IDNCT05841199

SponsorImperial College London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06-02

Contact for this trial

Rahul Bahl

+44 20 7594 1093 r.bahl@imperial.ac.uk

View on ClinicalTrials.gov More Ventricular Tachycardia trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in coronary flow in participants with different levels of coronary microvascular function.

Timeframe: At baseline and during simulated VT

Change in coronary flow in participants immediately before and after PCI

Timeframe: At baseline and during simulated VT, immediately before PCI and after PCI

Change in blood pressure in participants with different levels of coronary microvascular function.

Timeframe: At baseline and during simulated VT

Change in blood pressure in participants before and after PCI

Timeframe: At baseline and during simulated VT, immediately before PCI and after PCI