The Adverse Event of Mitotane Therapy in Patients With Adrenocortical Carcinoma

Inclusion Criteria: Age ≥ 18 years old and ≤ 75 years Diagnosis of Patients with adrenocortical cancer Gender: males and females Provide written informed consent Satisfactory compliance Exclusion Criteria: Patients with renal insufficiency (Cr\>2 times the upper limit of normal). Patients with a history of liver cirrhosis. Patients who are currently using corticosteroids. Patients with cardiac insufficiency (NYHA cardiac function classification grade 3 and above or EF\<50%). Patients with stroke and acute myocardial infarction in the past 6 months. Patients during pregnancy and lactation