Everolimus Aging Study

Inclusion Criteria: Adults aged 55-80 years old * Free of overt chronic disease * Willing to provide informed consent * Willing to comply with all study procedures and be available for the duration of the study * Able to use and be contacted by the telephone * Ability to take oral medication * Insulin Resistant defined by HOMA-IR greater than or equal to 1.5 or prediabetic defined as: * impaired fasting glucose (100-125 mg/dL) * HbA1c (5.7-6.4 percent) * glucose 2 hours after a 75 gram oral glucose tolerance test (140-199 mg/dL) * previous diagnosis of prediabetes in the past year * Not planning to change diet or physical activity status * Adequate organ function as indicated by standard laboratory tests: hematology (complete blood count), clinical chemistry and urinalysis * Females of childbearing potential must have a negative urine pregnancy test before DEXA and before the oral glucose tolerance test (OGTT). A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: * Has not undergone a hysterectomy or bilateral oophorectomy; or * Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months) * Women of childbearing potential in sexual relationships with men must use an acceptable method of contraception from 30 days prior to enrollment until 4 weeks…