The purpose of this study is to compare two different antibiotic regimens and techniques during total shoulder arthroplasty. Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups.
Age range
18 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Systemic Levels of Vancomycin
Timeframe: 24 hours
Vancomycin Levels in the Initial Deltoid
Timeframe: 24 hours
Vancomycin Levels in the Humeral Head
Timeframe: 24 hours
Levels of Vancomycin in Synovium
Timeframe: 24 hours
Levels of Vancomycin in Labrum
Timeframe: 24 hours
Levels of Vancomycin in Glenoid Reaming
Timeframe: 24 hours
Levels of Vancomycin in Bicep Tendon
Timeframe: 24 hours
Levels of Vancomycin in End Deltoid
Timeframe: 24 hours
Vancomycin Levels in Bicep Tendon
Timeframe: 24 hours