CompletedPhase 4

Effect of Pre-emptive Dose of Prednisone Versus Placebo in Impacted Third Molar Surgery

Italy34 participantsStarted 2022-02-01

Plain-language summary

The present study proposes to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus and pain after surgical removal of the mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Who can participate

Age range18 Years – 32 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18 to 32 years who required both M3M extractions were recruited * Good health status * Indication to surgical extraction of both M3M * Complete root formation * Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification Exclusion Criteria: * Person under the age of 18 or over 32 * Allergy or contraindications to administration of corticosteroids * Acute infection in any of the teeth to be extracted * Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease * Pregnancy or breastfeeding * History of treatment with antiresorptive drugs * Chronic kidney disease * History of systemic corticosteroid therapy in the past 4 weeks

What they're measuring

Change in facial swelling

Timeframe: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery

Change in facial swelling

Timeframe: Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery

Trial details

NCT IDNCT05830747

SponsorUniversity Magna Graecia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-25

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