SuspendedEarly Phase 1

Measuring Acute Drug Demand in Humans

Stopped: The trial is currently paused during a move to a new institution and acquisition of the new IRB approval at University of Maryland, Baltimore

United States75 participantsStarted 2023-08-08

Plain-language summary

This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 65 years old * Meets Diagnostic and Statistical Manual-5 criteria for Opioid Use Disorder (OUD) (moderate or severe) * Lifetime substance use history criterion \[blinded\] * Medically cleared to take suvorexant and blinded study medications * Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests Exclusion Criteria: * Pregnant or breast feeding * Seeking opioid use treatment * Significant mental health or physical disorder that is expected to interfere with study participation as assessed by the study physicians or medical staff * Known contraindications or allergies to suvorexant and/or the blinded study medications

What they're measuring

Demand Intensity

Timeframe: Upon completion of experimental session (~8 hours post drug administration)

Demand Elasticity

Timeframe: Upon completion of experimental session (~8 hours post drug administration)

Cross-Price Elasticity

Timeframe: After Experimental Session 4

Trial details

NCT IDNCT05829655

SponsorUniversity of Maryland, Baltimore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-10-31

View on ClinicalTrials.gov More Opioid Use Disorder trials