A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary Obstructions

Inclusion Criteria: * Malignant biliary stricture * participants have or will have a biopsy-confirmed pancreaticobiliary or ampullary malignancy that have agreed to undergo radiofrequency ablation (RFA) with placement of biliary stents * Patients with life expectancy greater than 3 months * Able to provide consent Exclusion Criteria: * Patients who are pregnant * Patients with cirrhosis * Patients with significant liver metastasis \>30% on radiologic imaging suggestive of poor liver function that will not improve despite endoscopic drainage. * Patients who have undergone prior biliary decompression stents or percutaneous drainage that cannot be removed at time of ERCP and thus preclude effective RFA * Patients with altered anatomy unable to undergo conventional ERCP (i.e., history of Roux-en-Y gastric bypass)