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Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism

China59 participantsStarted 2021-09-01

Plain-language summary

The purpose of our research is to evaluate the value of ACTH stimulation in AVS especially in lateralization is still controversial.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Diagnosed as primary aldosteronism.
✓. AVS was performed and conservative treatment or adrenalectomy was performed according to the results.
✓. Regular follow-up was performed.

Exclusion criteria

✕. Adrenal function evaluation suggests that it is complicated with hypercortisolism, subclinical hypercortisolism and pheochromocytoma.
✕. Familial aldosteronism.
✕. .Adrenal mass is considered to be malignant, or pathology suggests adrenocortical carcinoma.
✕. .Complicated with severe infection, respiratory and circulatory failure, advanced tumor, severe. hepatic and renal insufficiency, neurological, psychiatric and immune deficiency diseases.
✕. .Drugs: discontinuation of β-receptor inhibitors, angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, thiazide diuretics \< 2 weeks, aldosterone receptor antagonists \< 4 weeks.
✕. .Pregnant and lactating women.

What they're measuring

Participants' personal information

Timeframe: 1 day

Physical assessments

Timeframe: 1 day

Screening test of primary aldosteronism（Supine standing test）

Timeframe: 1 day

Screening test of primary aldosteronism（Supine standing test）

Timeframe: 1 day

Confirmatory test of primary aldosteronism（Captopril test）

Timeframe: 1 day

Confirmatory test of primary aldosteronism（Captopril test）

Timeframe: 1 day

circadian cortisol rhythm

Timeframe: 1 day

circadian cortisol rhythm

Timeframe: 1 day

Cortisol metabolism

Trial details

NCT IDNCT05826080

SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-10-01

Contact for this trial

Ping LI, MD

86-25-83-105302 li78321@yeah.net

View on ClinicalTrials.gov More Primary Aldosteronism trials

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Diagnosed as primary aldosteronism.
✓. AVS was performed and conservative treatment or adrenalectomy was performed according to the results.
✓. Regular follow-up was performed.

Exclusion criteria

✕. Adrenal function evaluation suggests that it is complicated with hypercortisolism, subclinical hypercortisolism and pheochromocytoma.
✕. Familial aldosteronism.
✕. .Adrenal mass is considered to be malignant, or pathology suggests adrenocortical carcinoma.
✕. .Complicated with severe infection, respiratory and circulatory failure, advanced tumor, severe. hepatic and renal insufficiency, neurological, psychiatric and immune deficiency diseases.
✕. .Drugs: discontinuation of β-receptor inhibitors, angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, thiazide diuretics \< 2 weeks, aldosterone receptor antagonists \< 4 weeks.
✕. .Pregnant and lactating women.

What they're measuring

Participants' personal information

Timeframe: 1 day

Physical assessments

Timeframe: 1 day

Screening test of primary aldosteronism（Supine standing test）

Timeframe: 1 day

Screening test of primary aldosteronism（Supine standing test）

Timeframe: 1 day

Confirmatory test of primary aldosteronism（Captopril test）

Timeframe: 1 day

Confirmatory test of primary aldosteronism（Captopril test）

Timeframe: 1 day

circadian cortisol rhythm

Timeframe: 1 day

circadian cortisol rhythm

Timeframe: 1 day

Cortisol metabolism