CompletedNot Applicable

The Impact of Estrogen Administration Duration in Hormonally Prepared Frozen Embryo Transfer Cycles

Turkey (Türkiye)420 participantsStarted 2020-01-01

Plain-language summary

This prospective controlled study aimed to investigate the effect of the duration of estrogen (E2) administration prior to progesterone (P) initiation on live birth rates (LBR) in frozen embryo transfer (FET) cycles. The study was conducted at a single tertiary-care in vitro fertilization (IVF) center and included 486 patients undergoing high-quality frozen blastocyst transfer in a hormone replacement therapy (HRT) cycle. Patients scheduled for E2 therapy were administered either 5-7, 8-10, or 11-13 days of treatment, depending on their presentation day. After the E2-only phase, if the endometrial thickness was above 7mm, P was initiated (daily 300mg of vaginal micronized P tablets), and FET was performed on the 6th day of P treatment. The primary outcome measure was LBR.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion Criteria: * Exogenous hormone preparation of the endometrial lining * High embryo quality ((≥2BB) according to Alpha criteria * Embryo transfer at the blastocyst stage Exclusion Criteria: * \- Patients whose treatments were canceled for any reason before the embryo transfer procedure * Patients who underwent embryo transfer in the cleavage stage * Presence of low-quality (\<2BB) blastocysts * \>15% loss of viability of the embryo during embryo thawing,

What they're measuring

live birth rate

Timeframe: 2 years

Trial details

NCT IDNCT05825885

SponsorAkdeniz University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

View on ClinicalTrials.gov More Duration of Estrogen Administration trials