Tafasitamab and Lenalidomide Followed by Tafasitamab and ICE as Salvage Therapy for Transplant Eligible Patients With Relapsed/ Refractory Large B-Cell Lymphoma

Inclusion Criteria: * Adult patient (age 18 or older) * Willing and able to provide written informed consent for the trial, assent when appropriate may be obtained per institutional guidelines * Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 * Considered transplant eligible by the treating physician * Measurable disease by CT (defined as \>= 1.5 cm in diameter) or one or more area of PET avid disease * Have received one line of prior chemo-immunotherapy (i.e. cyclophosphamide, doxorubicin, prednisone, rituximab and vincristine \[R-CHOP\]). Note that corticosteroids for palliation of symptoms and radiation consolidation are not considered a line of therapy for purposes of eligibility determination * Eligible histologic diagnosis includes: Diffuse large B cell lymphoma not otherwise specified (NOS), T cell histiocyte rich large B cell lymphoma, primary mediastinal B Cell lymphoma, follicular lymphoma grade 3B, high grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangement, high grade B cell lymphoma NOS, DLBCL transformed from follicular lymphoma, DLBCL transformed from marginal zone lymphoma, DLBCL leg type, and B cell lymphoma unclassifiable (with features intermediate between DLBCL and classical Hodgkin's lymphoma) * Absolute neutrophil count \>= 1000 / mcL * Platelets \>= 75,000 / mcL in absence of transfusion support within 7 days of determining eligibility * Hemoglobin \>= 8.0 g/dL, with exception of cases in which cytopenias are due to marrow…