UnknownPhase 2

Early Versus Conventional Cessation of Hydrocortisone in Septic Shock

Thailand160 participantsStarted 2023-07-05

Plain-language summary

Septic shock is one of the causes of death in ICU and hospital. Refractory shock is the problem which healthcare providers should recognize though it is difficult to handle with. The corticosteroid called hydrocortisone is one of the treatment in refractory septic shock which requires vasopressor to maintain blood pressure. In recovery phase of septic shock and weaning off vasopressor, there is no definite way to taper off hydrocortisone.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient \>= 18 years old * Diagnosis Septic shock from the definition of SEPSIS III criteria in intensive care unit or medicine ward or surgical ward at Siriraj hospital * Received at least 1 catecholamines and hydrocortisone at least 200 mg/d * Maintain mean arterial pressure \>= 65 mmHg even if titrate down catecholamines until low dose (\<=0.1 mcg/kg/min) Exclusion Criteria: * Patient sign Do not resuscitation and terminally ill * Pregnancy * Need long term steroid use due to other medical condition

What they're measuring

Composite adverse events of early versus conventional cessation of hydrocortisone

Timeframe: within 14 days after randomization or until discharge from hospital, whichever came first

Trial details

NCT IDNCT05818826

SponsorMahidol University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04

Contact for this trial

Surat Tongyoo, Doctor

+24197764 surat.ton@mahidol.ac.th

View on ClinicalTrials.gov More Septic Shock trials