TerminatedNot Applicable

The Long-term Safety and Effect of Renal Denervation

Stopped: Guidewires used in the study are no longer manufactured

United Kingdom9 participantsStarted 2021-04-27

Plain-language summary

The goal of this observational study is to learn about the effects of renal denervation in patients with resistant hypertension. The main question it aims to answer is: What are the long term effects of renal denervation on blood pressure and flow within the arteries? Participants will undergo an assessment of their blood pressure, echocardiogram and invasive measurements of blood pressure and flow in the aorta and renal arteries before undergoing the renal denervation procedure. 6 months later these assessments will be repeated.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systolic blood pressure \>160mmHg despite 3 antihypertensive agents * eGFR \>45 Exclusion Criteria: * Secondary causes of hypertension * Prior renal artery intervention * Renal insufficiency * Significant stenotic valvular heart disease * Myocardial infarction, unstable angina or stroke within the preceding 6 months

What they're measuring

Change in systolic blood pressure

Timeframe: At baseline and at 6 months

Trial details

NCT IDNCT05818813

SponsorImperial College Healthcare NHS Trust

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-04-16

View on ClinicalTrials.gov More Hypertension trials