Association of Apical Periodontitis With Chronic Kidney Disease

Inclusion Criteria: * Known patient of CKD Stages 1,2,3,4 \& 5 with estimated glomerular filtration rate \[eGFR; MDRD\] with mature permanent teeth. * \> 18 years * \> 8 natural teeth. * Complete medical \& dental history including panoramic radiographs of maxilla \& mandible Exclusion Criteria: * Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism). * Pregnancy, lactation \& contraceptives. * Systemic conditions that contra indicates dental treatment. * Use of antibiotics \& anti-inflammatory in last 3 months * Need for antibiotic prophylaxis. * Hepatitis C and B virus. * Patients on steroids.