CompletedNot Applicable

Antimicrobial Photodynamic Therapy in Patients With Periodontal Disease and Type 2 Diabetes Mellitus

24 participantsStarted 2016-01-03

Plain-language summary

Objectives: This study aimed to determine the effect of concomitant antimicrobial photodynamic therapy (aPTD) on periodontal disease and glycaemic control in patients with type 2 diabetes mellitus (T2DM). Clinical Relevance: aPTD is a noninvasive adjunctive therapy that can positively influence the periodontal treatment outcome.

Who can participate

Age range

40 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 40 and 75 years * Diabetes Mellitus type 2 with an HbA1c value \> 7.0%, * At least ten teeth in the Maxilla and Mandible * At least four teeth with a probing pocket depth ≥ 5 mm and bleeding on probing. Exclusion Criteria: * Antibiotic treatment in the last four months * Periodontal treatment in the last six months * Any change in Antihyperglycaemic treatment three months prior to participation * Pregnant women * Lactating women * Smokers * Former smokers who had stopped smoking less than five years before participation

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Probing pocket depth (PPD)

Timeframe: At baseline

Probing pocket depth (PPD)

Timeframe: 90 days after treatment

Bleeding on probing (BOP)

Timeframe: At baseline

Bleeding on probing (BOP)

Timeframe: 90 days after treatment

Clinical attachment level (CAL)

Timeframe: At baseline

Clinical attachment level (CAL)

Timeframe: 90 days after treatment

The presence of five periodontal pathogens, Aggregatibacter actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Prevotella intermedia (PI), Tanerella forsythia (TF) and Treponema denticola (TD),

Timeframe: At baseline

Trial details

NCT IDNCT05816941

SponsorUniversity of Ljubljana

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-01-03

View on ClinicalTrials.gov More Periodontal Diseases trials

Plain-language summary

Who can participate

Age range

40 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Probing pocket depth (PPD)

Timeframe: At baseline

Probing pocket depth (PPD)

Timeframe: 90 days after treatment

Bleeding on probing (BOP)

Timeframe: At baseline

Bleeding on probing (BOP)

Timeframe: 90 days after treatment

Clinical attachment level (CAL)

Timeframe: At baseline

Clinical attachment level (CAL)

Timeframe: 90 days after treatment

Timeframe: At baseline