CompletedNot Applicable

Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity

256,659 participantsStarted 2012-01-01

Plain-language summary

The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018 Exclusion Criteria: * Lack of data of PFAS levels in municipal drinking water (entire localities excluded) * Mothers not living in the study area consistently between first trimester and four years prior to birth

What they're measuring

Birth outcome - birthweight

Timeframe: at birth

Birth outcome - Small for gestational age (SGA)

Timeframe: at birth

Birth outcome - Large for gestational age (LGA)

Timeframe: at birth

Birth outcome - major congenital malformations

Timeframe: at birth

Maternal health - Gestational hypertension/preeclampsia

Timeframe: during gestation

Maternal health - Gestational diabetes mellus

Timeframe: during gestation

Trial details

NCT IDNCT05810545

SponsorKarolinska Institutet

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-12-31

View on ClinicalTrials.gov More Birth Weight trials