Low-load Resistance Training With Blood Flow Restriction in People With Parkinson's Disease (NCT05806775) | Clinical Trial Compass
CompletedNot Applicable
Low-load Resistance Training With Blood Flow Restriction in People With Parkinson's Disease
United States20 participantsStarted 2023-04-01
Plain-language summary
The study's objective is to determine the feasibility of low-load resistance training with blood flow restriction in people who have advanced Parkinson's disease and impaired mobility using a mixed-methods convergent parallel design in a single cohort. The study's long-term goal is to develop clinically feasible exercise interventions that are effective at improving mobility, participation, and quality of life for people with advanced Parkinson's disease.
Who can participate
Age range
18 Years – 89 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults ages 18-89 with neurologist-confirmed diagnosis of PD
* H\&Y Stage 2 (bilateral involvement without postural instability) up to H\&Y Stage 4 (severe disease)
* Able to provide informed consent
Exclusion Criteria:
* H\&Y Stage 1 (unilateral involvement only) or less
* H\&Y Stage 5 (wheelchair or bed bound)
* Unable to provide consent or diagnosis of dementia
* History of deep venous thrombosis/pulmonary embolism, peripheral vascular disease, thrombophilia or other clotting disorders; report of easy bruising
* Any comorbid conditions or pain that substantially affects ability to safely complete rehabilitation (e.g. neurologic, vascular, cardiac problems, orthopedic, or ongoing medical treatments) as determined by a neurologist or physical therapist
* Currently undergoing supervised resistance training with a physical therapist or other exercise professional
* Using Blood Flow Restriction currently or in the previous 3 months prior to enrollment
* Cannot tolerate BFR pressure cuff inflated to 60% of total limb occlusion pressure during baseline assessment
* PD-related medication change in the month prior to enrollment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Knee Extension
Timeframe: Measured at Baseline (Week 0) and Post Test (Week 9)
2
Change in Ankle Plantarflexion
Timeframe: Measured at Baseline (Week 0) and Post Test (Week 9)
3
Change in Elbow Extension
Timeframe: Measured at Baseline (Week 0) and Post Test (Week 9)