Proteomics and Genomics Combined With CT to Predict CVD

Inclusion Criteria: * Adult patients between 50 and 75 years old * Subjects at intermediate to high risk for ASCVD * Asymptomatic patients without cardiac chest pain * Evidence of atherosclerosis on baseline CCTA Exclusion Criteria: * Renal insufficiency, defined as eGFR \< 30 ml/min * History of cardiovascular events (myocardial infarction, peripheral artery disease and ischemic stroke) * Use of lipid lowering therapy other than statin, ezetimibe or bempedoic acid monotherapy * Change in lipid lowering therapy in the last 6 months * Use of more than two antihypertensive agents * No coronary atherosclerosis at baseline imaging * Active malignancy requiring treatment * Atrial fibrillation * Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator * Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.