RecruitingNot Applicable

Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

Hong Kong120 participantsStarted 2023-07-01

Plain-language summary

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients hospitalized for heart failure and pleural effusion * Pleural tapping indicated for pleural fluid analysis. * Aged 18 years old or above Exclusion Criteria: * History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space. * History of surgical decortication or pleurodesis in the ipsilateral pleural space. * Ipsilateral thoracic or cardiac surgery in the past 3 months. * Failure to obtain informed consent due to the patient's refusal or cognitive impairment.

What they're measuring

Comparison of the diagnostic performance of PF NTproBNP level in the diagnosis of HF-associated pleural effusions with other conventional biochemical criteria

Timeframe: 24 months

Trial details

NCT IDNCT05797649

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-11-30

Contact for this trial

Christopher Chan, MBChB

35053396 christopherchan@cuhk.edu.hk

View on ClinicalTrials.gov More Pleural Effusion trials