Clinical Impact of Patient-ventilator Asynchrony (NCT05796297) | Clinical Trial Compass
CompletedNot Applicable
Clinical Impact of Patient-ventilator Asynchrony
France35 participantsStarted 2023-06-01
Plain-language summary
The investigator wish to carry out this study to explore the link between patient-ventilator asynchrony with the efficiency and tolerance of NIV but also the quality of life in patients with chronic respiratory failure on long-term ventilation.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria :
* Women and Men aged of at least 18 years old.
* NIV equipment since 6 months ( at least)
* Chronic respiratory failure requiring NIV equipment defined by clinical symptoms (asthenia, excessive daytime sleepiness, headache, dyspnea) and:
In case of obstructive diseases :
Daytime hypercapnia (PaCO2 \> 55 mmHg) or Daytime hypercapnia between 50-54 mmHg associated with nocturnal desaturations (at least 5 min below 88% saturation) or episodes of frequent hypercapnic exacerbations (at least 2 over the last 12 months)
In case of restrictive diseases :
Daytime hypercapnia (PaCO2\>6 kPa (kilopascal) or 45 mm Hg) or Nocturnal desaturation (SaO2 \< 88%) for at least 5 minutes without obstructive sleep apnea syndrome (OSAS) found or Marker of progression of neuromuscular damage (Maximum inspiratory pressure \< 60 cm H2O and forced vital capacity (FVC) less than 50% of theory)
* NIV's start from at least 6 months.
* Patient who did not object to being included in the study.
* Patient in stable condition without exacerbation (for at least 3 months)
Exclusion Criteria :
* Minor patient
* Pregnant or breastfeeding women
* Adult patient subject to enhanced protection, deprived of liberty by judicial or administrative decision.
* Patient who is physically or psychologically unable to follow the protocol in an informed manner.
* Patient with chronic respiratory failure requiring mechanical ventilation by tracheotomy
* Patient having changed center or service provid…