Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol

Please see https://docs.google.com/spreadsheets/d/1ltZHHv6AvMkPBbSp\_9c0dtQ0XMmBc00d4jaRId5ovaA/edit?usp=sharing or Appendix A (https://drive.google.com/drive/folders/1a-1uRt73kVywEoV8L0cEmDNgaqYEIudT?usp=sharing) for full code and algorithm definitions. Medicare timeframe: 2008 to 2019 (end of data availability). Inclusion Criteria: * 1\. Aged \>/= 65 years on the index date * 2\. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date * 3\. At least 1 inpatient claim or 2 outpatient claims with hypertension diagnosis recorded in 365 days prior to drug initiation Exclusion Criteria: * 1\. Prior history of dementia measured anytime prior to cohort entry date * 2\. Prior history of nursing home admission in the 365 days prior to the cohort entry date * 3\. Prior use of Propranolol, Carvedilol and Atenolol, Bisoprolol, Sotalol * 4\. Use of Propranolol, Carvedilol and Atenolol, Bisoprolol, Sotalol concomitantly on index date