Not Yet RecruitingNot Applicable

Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

United States25 participantsStarted 2026-07

Plain-language summary

Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female * Age 18-55 * Endorse good health with no history of mental or physical illness or implanted metal * English as a primary language * Capacity to consent * Negative urine pregnancy test if a female of childbearing potential * Willingness to adhere to the tFUS and MRI study schedule Exclusion Criteria: * Any psychotropic medication is taken within 5 half-lives of procedure time * Any head trauma resulting in loss of consciousness * Personal or family history of neurological illness or injury * Alcohol or substance abuse or dependence (other than tobacco) in the past week * Diagnosis or current treatment (pharmacological or otherwise) of any psychiatric condition * Pregnancy * Personal or family history of seizures or epilepsy * Claustrophobia or inability to stay still in the MR scanner environment * Any metal in the body * Other contraindications to electrical or electromagnetic stimulation * Hair in dreadlocks, braids, or weave * Diagnosis of COVID-19 in the past 14 days * Inability to adhere to the treatment schedule.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Motor Evoked Potential Amplitude

Timeframe: Immediate Post-Stimulation

Trial details

NCT IDNCT05792020

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Lisa M McTeague, Ph.D.

8437928274 mcteague@musc.edu

View on ClinicalTrials.gov More Healthy trials

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.