The Efficacy and Safety of Rifaximin Treatment

1. Inclusion Criteria: * The confirmed HBsAg positive patients with chronic hepatitis B are defined as HBsAg positive for at least 6 months or evidence of chronic HBV infection; * Acute onset, progressive deepening of jaundice, serum total bilirubin (TB) ≥ 85umol/L and severe coagulation dysfunction, international standardized ratio (INR) ≥ 1.5 or plasma prothrombin activity (PTA)\<40% * The score of the psychological test scale of hepatic encephalopathy is less than - 4 points or mild to moderate (degree I or II) manifestations of hepatic encephalopathy, including the decline of computational ability, timing and orientation, personality change, lethargy, and positive flapping wing tremor. * Be able and willing to provide informed consent and comply with the test requirements. 2. Exclusion Criteria: * There are definite infections or hepatorenal syndromes during screening; * Upper gastrointestinal bleeding occurred within 1 week before screening; * Have used sedative drugs such as "benzodiazepines" or other psychotropic drugs within one week before screening; * Those with severe primary heart, lung, kidney and other important organ dysfunction affecting life expectancy; * HIV infection; * Uncontrolled malignant tumor, nerve and mental abnormality; * Patients who are allergic to the study drugs and excipients; * Pregnant or lactating women; * In the late stage of liver failure, MELD score\>35; * Other circumstances in which the resea…