Development of a Newborn Screening Assay for Angelman Syndrome and Prader-Willi Syndrome

Inclusion Criteria: * Diagnosed with Angelman Syndrome, confirmed by molecular testing (deletion of maternal allele of chromosome 15q11-q13, paternal uniparental disomy, and imprinting center defects) * Diagnosed with Prader-Willi Syndrome, confirmed by molecular testing (deletion of paternal allele of chromosome 15q11-q13, maternal uniparental disomy, and imprinting center defects) * Angelman Syndrome or Prader Willi Syndrome: Current patient at UW Health in the Madison, Wisconsin metropolitan area * Healthy controls 18 years old or older and have not received a diagnosis of Angelman syndrome or Prader Willi syndrome Exclusion Criteria: * Angelman Syndrome/Prader Willi Syndrome: family requires a translator for medical visits * Healthy Controls: Participants are unable to consent and complete study procedures in English.