Growth Factor Enhanced Matrix With Subepithelial Connective Tissue Graft or Collagen Membrane in … (NCT05782751) | Clinical Trial Compass
CompletedPhase 4
Growth Factor Enhanced Matrix With Subepithelial Connective Tissue Graft or Collagen Membrane in Treatment of Gingival Recession
Egypt10 participantsStarted 2019-01-01
Plain-language summary
The study aimed to compare, the effectiveness of Growth Factor Enhanced Matrix (GEM 21s) ® combined either with free connective tissue graft or collagen membrane in the treatment of Miller class II gingival recession.
Who can participate
Age range
25 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* lack of any related medical issues that contraindicate periodontal surgery,
* optimum adherence as confirmed by a positive attitude towards oral hygiene, and successfully showing up for treatment appointments.
* No history of any medications in the previous six months that may interfere with periodontal surgery Gingival thickness for the selected sites should be \> 1mm (as measured 2mm apical to gingival margin),
* Clinical attachment level ≥ 4mm measured from cemento-enamel junction till the deepest probing depth.
Exclusion Criteria:
* the presence of class V caries or restoration in the site to be treated,
* previous mucogingival surgery at the selected site.
* Teeth that are tilted, rotated, or have any occlusal abnormalities.
* Smokers and pregnant patients were excluded from the participation.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recession width
Timeframe: up to 6 months
2
recession depth
Timeframe: up to 6 months
3
Height of keratinized tissue
Timeframe: up to 6 months
4
Gingival thickness (Gingival biotype)
Timeframe: up to 6 months
5
radiographic measurements of facial bone level, thickness and density