Not Yet RecruitingNot Applicable

Rehabilitating Vision Loss in Veterans With Age-Related Macular Degeneration

United States20 participantsStarted 2026-03-01

Plain-language summary

This study will help develop new methods of rehabilitating Veterans with vision loss due to Age-related macular degeneration.

Who can participate

Age range50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. The subject is a Veteran.
✓. The subject is 50 years of age.
✓. The subject has best-corrected visual acuity (BCVA) of 20/40 or worse in each eye, as determined by the standard CNVAMC optometric tests.
✓. The subject has visual field deficit of 10O in either eye as determined by the Octopus 900 perimetry (Haag-Streit Diagnostics, Haag-Streit USA, Mason, OH) administered by CNVAMC. (When the deficit/s are binocular, they do not necessarily have to be in binocularly corresponding positions.)
✓. The subject has received a formal clinical diagnosis of age-related macular degeneration (AMD) in one or both eyes (binocular AMD does not necessarily have to be in binocularly corresponding positions)7,8,56.
✓. The subject has visual deficit in either eye (wavy lines and/or missing/darkened areas on the grid) determined by the standard Amsler Grid Test7,8,56.
✓. The subject has not yet started any rehabilitative treatment for AMD-related vision loss.
✓. Both eyes of the subject are otherwise age-appropriately stable, and neither eye has any other visual defects, as determined by the standard CNVAMC ophthalmological examination.

Exclusion criteria

✕. According to the patient's VA clinical records, the patient has one or more clinically diagnosed neurological disorder.
✕. According to the patient's VA clinical records, the patient has one or more clinically diagnosed cognitive deficits.
✕. According to the patient's VA clinical records, the patient has been clinically diagnosed with a psychiatric disorder that would make it unduly uncomfortable or otherwise clinically inadvisable for the subject to participate in the study.
✕. According to the patient's VA clinical records, according to the patient, or both, the patient has motor disorder/s that would make it unduly uncomfortable or otherwise clinically inadvisable for the subject to participate in the study.
✕. According to the patient's VA clinical records, according to the patient, or both, the patient has an MR-incompatible implant and/or another condition (e.g., claustrophobia) that would make it inadvisable for the subject to participate in MR imaging or any other study procedure.
✕. The patient does not understand the informed consent information and/or the standard study instructions in spoken or written English, and/or is unable to follow study instructions. \[The purpose of this exclusion criterion, required by the AU IRB, is to help ensure that the subjects adequately understand all the information relevant to providing informed consent, as well as the study instructions.\]
✕. Inability to give informed consent to participate in the study.
✕. Pregnancy, as determined by a standard urine test for pregnancy.

What they're measuring

Accuracy of object recognition

Timeframe: 6-10 weeks

Response of brain regions of interest (ROI) as reflected in the BOLD (blood oxygenation level-dependent) response

Timeframe: 6-10 weeks

Trial details

NCT IDNCT05780931

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeOBSERVATIONAL

Primary completion2026-06-30

Contact for this trial

Jay Hegde, PhD

(706) 733-0188 jay.hegde@va.gov

View on ClinicalTrials.gov More Age-related Macular Degeneration (AMD) trials