Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant As PONV Prevention (NCT05773950) | Clinical Trial Compass
By InvitationNot Applicable
Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant As PONV Prevention
South Korea144 participantsStarted 2023-08-18
Plain-language summary
As a preventive for postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery, the investigators shall investigate the efficacy of the triple therapy of dexamethasone, palonosetron, and fosaprepitant comparing to dual therapy of dexamethasone and palonosetron.
Who can participate
Age range
19 Years – 49 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients undergoing laparoscopic gynecological surgery.
* Adults between the ages of 18 and 50
* American Society of Anesthesiologists Physical Status (ASA physical status I, II
Exclusion Criteria:
* American Association of Anesthesiologists physical standards (ASA physical status III or higher)
* Children under the age of 19
* Adults over 49 years of age
* Diabetes Mellitus
* Pregnant or lactating women
* Patients with a history of allergy or contraindications for use of the study drug
* Patients who did not understand this study or expressed their refusal.
* Patients with a history of serious psychologic disease that may affect the patient evaluation
* Patients taking serotonergic drugs
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
the incidence of Postoperative nausea and vomiting