Hedonic and Homeostatic Appetite Control in Obesity and Type 2 Diabetes in the Context of Meal an… (NCT05768958) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Hedonic and Homeostatic Appetite Control in Obesity and Type 2 Diabetes in the Context of Meal and Exercise Timing
Denmark58 participantsStarted 2023-03-22
Plain-language summary
The overall aim is to investigate effects of acute exercise on ad libitum energy intake and study whether this differs between morning and evening in individuals with overweight/obesity with or without type 2 diabetes (T2D). Furthermore, the aim is to examine the role of hedonic and homeostatic drivers of appetite control in obesity and T2D in the context of meal and exercise timing.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults with overweight or obesity (BMI \>25 kg/m2) with and without T2D
* HbA1c ≥48 mmol/mol for people with T2D
Exclusion Criteria:
* Not able to eat ad libitum meal
* Not able to perform the exercise bout
* Daily smoking
* For women: Pregnancy / planned pregnancy (within the study period) / lactating
* Self-reported history of an eating disorder in the past 3 years
* Self-reported weight change (\>5 kg) within three months prior to inclusion
* Treatment with antidepressants
* Treatment with fast acting insulin, combination insulin products and sulfonylureas
* Alcohol/drug abuse or in treatment with disulfiram (antabus) at time of inclusion
* Uncontrolled medical issues including but not limited to cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, gastrointestinal, or psychiatric disease; diabetes or other endocrine disease; immunosuppression
* Current treatment with medication which significantly affect appetite or energy balance (e.g., GLP-1 receptor agonists)
* Bariatric surgery
* Unable to understand the informed consent and the study procedures
* Concomitant participation in intervention studies
* Incapable of understanding Danish
What they're measuring
1
Ad libitum energy intake (KJ) after exercise compared with rest
Timeframe: Measured after meal consumption at t = 30 minutes