DIagnostic Biomarkers and Symptoms in Patients With Alzheimer's Disease and Lewy bodY Dementia (NCT05768425) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
DIagnostic Biomarkers and Symptoms in Patients With Alzheimer's Disease and Lewy bodY Dementia
Denmark55 participantsStarted 2023-02-01
Plain-language summary
This a study to improve diagnosis of dementia with Lewy bodies with RT-QuIC in different biospecimens.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria for healthy controls (HC):
* Age 18 - 40 years of age
* Able to cooperate as evaluated by the primary investigator (PI)
* Able to give informed consent
Exclusion criteria
* Signs of neurological/psychiatric conditions
* Known genetic neurodegenerative disease in close family
Inclusion criteria for patients with Dementia with Lewy Bodies (DLB):
* Probable DLB (McKeith et al., 2017) or MCI-LB (McKeith et al., 2020)
* Age \> 50 years of age
* Able to give informed consent
* Able to cooperate as evaluated by the PI
* MCI, mild or moderate dementia, and MMSE \> 18
Exclusion criteria for patients with DLB:
* Patients not able to give informed consent.
* Current alcohol or drug abuse
* Terminal illness
* Diagnosed with major neurological/psychiatric conditions other than DLB.
Inclusion criteria for controls (patients with Alzheimer's disease (AD)):
* Probable AD (McKhann et al., 2011) or MCI-AD (Albert et al., 2011)
* Age \> 50 years of age
* Able to give informed consent
* Able to cooperate as evaluated by the PI
* MCI, mild or moderate dementia, and MMSE \> 18
Exclusion criteria for controls (patients with AD):
* Patients not able to give consent.
* Current alcohol or drug abuse
* Terminal illness
* Diagnosed with major neurological/psychiatric conditions other than AD.
What they're measuring
1
Diagnostic accuracy of Real-time quaking-induced conversion
Timeframe: 24 months
2
Diagnostic accuracy of Real-time quaking-induced conversion
Timeframe: 24 months
3
Diagnostic accuracy of Real-time quaking-induced conversion