CompletedPhase 4

Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis

Lebanon75 participantsStarted 2021-03-01

Plain-language summary

the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III periodontitis. The main question it aims to answer is: is there a difference between HA and red i-prf when used as an adjunct to SRP in terms of efficacy? Participants who are eligible will be assigned to one of the treatment groups: * Group 1= receives HA+ SRP * Group 2= receives red i-prf + SRP * Group 3= receives only SRP Researchers will compare Groups 1,2 and 3 to see if there's a difference in the periodontal parameters measured.

Who can participate

Age range

20 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * clinical periodontal loss and radiographic bone loss of stage III/grades A and B with no history of systemic disease. * at least four periodontal sites with a pocket depth of six mm or greater * radiographic evidence of bone loss extending to the middle third of the root * clinical attachment loss of five mm or more Exclusion Criteria: * uncontrolled systemic conditions (uncontrolled diabetes or uncontrolled hypertension) * bleeding disorders, or on anticoagulant therapy * alcohol users * pregnant or lactating females * heavy smokers (more than ten cigarettes per day) * chemo or radio therapy * antibiotic/anti-inflammatory drugs over the last three months before treatment.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Clinical Attachment Level

Timeframe: 4 weeks

Probing Depth

Timeframe: 4 weeks

Trial details

NCT IDNCT05768243

SponsorBeirut Arab University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-24

View on ClinicalTrials.gov More Periodontitis Chronic Generalized Severe trials