UnknownNot Applicable

Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders

China1,198 participantsStarted 2023-03-14

Plain-language summary

To compare the difference in cumulative live birth rates within one year between double stimulations protocol and two-cycle antagonist protocol in poor ovarian responders.

Who can participate

Age range20 Years

SexFEMALE

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Inclusion criteria

✓. Women diagnosed with Poseidon criteria or expected poor ovarian responder （the number of oocyte retrieval ≤9）
✓. Women aged ≥20 years old
✓. Women who are undergoing their first or second ART cycles
✓. Women who are undergoing IVF,ICSI or PGT-A cycles
✓. Women with the number of oocyte retrieval ≤9 after their first ovarian stimulation cycle since radomization, and the number of follicle measuring 8mm or larger ≥3

Exclusion criteria

✕. Women with RIF or RSA
✕. Women diagnosed with uterine abnormalities including uterine malformations, adenomyosis, submucosal fibroids, uterine adhesions or endometrial polyps
✕. Women with untreated hydrosalpinx that is visible under pelvic ultrasound
✕. Women with chromosomal abnormalities, or women who are undergoning PGT-SR or PGT-M cycles
✕. Women with a history of canceled FET cycle(s) due to a thin endometrium (\<7mm)
✕. Man with operation to get sperm

What they're measuring

Cumulative live birth rate

Timeframe: 36 months

Trial details

NCT IDNCT05765968

SponsorShandong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

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