Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults (NCT05764824) | Clinical Trial Compass
CompletedNot Applicable
Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults
United States67 participantsStarted 2023-10-01
Plain-language summary
This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.
Who can participate
Age range
65 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 65-99 years
* Able to travel to Brigham and Women's Hospital for 4 clinic visits
Exclusion Criteria:
* Known allergies to blueberries
* Unable to abstain from blueberry consumption during the study period
* Inability to provide informed consent
* Planned major surgery during study period or recent major surgery up to 3 months before recruitment
* Organ transplant
* Plan to move out of greater Boston area during the study period
* Diagnosis of dementia, severe cognitive decline, end-stage renal disease, substance abuse, insulin-dependent diabetes mellitus, major cancer excluding non-melanoma skin cancer, and schizophrenia.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in plasma concentration of neurofilament light (NFL) between baseline and 24 weeks
Timeframe: Baseline and at 24 weeks after the intervention
2
Change in plasma concentration of phosphorylated tau (pTau-181) between baseline and 24 weeks
Timeframe: Baseline and at 24 weeks post intervention